Steven Almo, Ph.D.

Co-Founder and Chair

Steven Almo is the Chairman of the Department of Biochemistry at Albert Einstein College of Medicine, where he is Professor of Biochemistry and of Physiology & Biophysics. Dr. Almo holds the Wollowick Family Foundation Chair in Immunology and is Director of Einstein’s Macromolecular Therapeutics Development Facility, a resource dedicated to the development and optimization of protein-based therapeutics. Dr. Almo is recognized for his broad contributions to structural biology and has published more than 300 papers. His laboratory has played key roles in the development and implementation of high-throughput approaches for protein production, structure determination and functional annotation. Dr. Almo received his Ph.D. in Biophysics from Harvard University, while working with Greg Petsko in the Chemistry Department at MIT, and is best known for his high resolution structural and biochemical characterization of the CTLA-4 and PD-1 immune checkpoint proteins and their respective ligands. The strategy for clonal-specific T cell modulation, which underlies Cue Biopharma’s therapeutic discovery pipeline, was developed in Dr. Almo’s laboratory.

Hidde Ploegh, Ph.D.

Hidde Ploegh is a member of the Program in Cellular and Molecular Medicine at Boston Children’s Hospital. Previously, Ploegh was a Professor of Biology at the Massachusetts Institute of Technology and a member of the Whitehead Institute for Biomedical Research. Dr. Ploegh is recognized for his contributions to molecular immunology and has published more than 400 papers, and is also the recipient of numerous awards. His laboratory has played a key role in developing sortase-based strategies for protein modification, and its use to modify sdAbs for use as reagents, diagnostics, and therapeutics. Dr. Ploegh is a correspondent of the Royal Dutch Academy of Sciences and a member of EMBO, the American Academy of Arts and Sciences and the National Academy of Sciences. He received his Ph.D. from the University of Leiden under Jack Strominger and is best known for his contribution to the understanding of antigen processing and immune evasion.

David Baker, Ph.D.

David Baker is a Professor of Biochemistry, Director of the Institute for Protein Design, Investigator of the Howard Hughes Medical Institute, and adjunct professor of Genome Sciences, Bioengineering, Chemical Engineering, Computer Science, and Physics at the University of Washington. His research group is focused on the prediction and design of macromolecular structures, interactions and functions. He is a member of the National Academy of Sciences and the American Academy of Sciences. His research group is a world leader in computational protein design and protein structure prediction. Dr. Baker received his Ph.D. in Biochemistry at the University of California, Berkeley in the laboratory of Randy Schekman (Nobel Prize recipient in 2013) and has published more than 400 peer-reviewed publications.  Dr. Baker is renowned in the field of protein design and protein structure prediction.

Jacques Banchereau, Ph.D.

Jacques Banchereau is Director of Immunological Sciences at the Jackson Laboratory. Dr. Banchereau’s laboratory is working to characterize the human immune system in both healthy and disease states by leveraging modern genomic tools. Dr. Banchereau served as director of the Baylor Institute for Immunology Research, as the Caruth Chair for Transplantation Immunology at the Baylor Research Institute in Dallas, Texas. Most recently, he was chief scientific officer of the Nutley, N.J. campus and senior vice president and head of the inflammation and virology discovery and translational research at Hoffmann-La Roche.

Karolina Palucka, M.D., Ph.D.

Karolina Palucka is an expert in cancer immunotherapy and how vaccines effect immune function. Dr. Palucka is Professor of Immunology at the Jackson Laboratory. Her lab specializes in human immunology and is focused on experimental immunotherapy. Her group pioneered the development of dendritic cell-based vaccines for patients with cancer or HIV.  Dr. Palucka served as the director of the Ralph M. Steinman Center for Cancer Vaccines and was the Michael A.E. Ramsay Chair for Cancer Immunology Research at the Baylor Institute for Immunology Research in Dallas, TX.