2020 Publications
Induced, but not natural, regulatory T cells retain phenotype and function following exposure to inflamed synovial fibroblasts
October, 2020
Yang S, Zhang X, Chen J, Dang J, Liang R, Zeng D, Zhang H, Xue Y, Liu Y, Wu W, Zhao J, Wang J, Pan Y, Xu H, Sun B, Huang F, Lu Y, Hsueh W, Olsen N, Zheng SG. Induced, but not natural, regulatory T cells retain phenotype and function following exposure to inflamed synovial fibroblasts. Sci Adv. 2020 Oct 28;6(44):eabb0606.
Continue readingEpigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation
May, 2020
Mikami N, Kawakami R, Chen KY, Sugimoto A, Ohkura N, & Sakaguchi S. Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation, Proc. Natl. Acad. Sci. 2020. 117 (22) 12258-12268.
Continue reading2018 Publications
Critical Role of TGF-β and IL-2 Receptor Signaling in Foxp3 Induction by an Inhibitor of DNA Methylation
February, 2018
Freudenberg K, Lindner N, Dohnke S, Garbe AI, Schallenberg S, Kretschmer K. Critical Role of TGF-β and IL-2 Receptor Signaling in Foxp3 Induction by an Inhibitor of DNA Methylation, Front. Immunol. 2018 Feb 2;9:125.
Continue reading2012 Publications
Antigen-specific transforming growth factor β–induced Treg cells, but not natural Treg cells, ameliorate autoimmune arthritis in mice by shifting the Th17/Treg cell balance from Th17 predominance to Treg cell predominance
May, 2012
Kong N, Lan Q, Chen M, Wang J, Shi W, Horwitz DA, Quesniaux V, Ryffel B, Liu Z, Brand D, Zou H, Zheng SG. Antigen-specific transforming growth factor β-induced Treg cells, but not natural Treg cells, ameliorate autoimmune arthritis in mice by shifting the Th17/Treg cell balance from Th17 predominance to Treg cell predominance. Arthritis Rheum. 2012 Aug;64(8):2548-58.
Continue reading2003 Publications
Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3
December, 2003
Chen W, Jin W, Hardegen N, Lei KJ, Li L, Marinos N, McGrady G, Wahl SM. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med. 2003 Dec 15;198(12):1875-86.
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