Careers

Senior Scientist/Principal Scientist,
Protein Purification Process Development

Cue Biopharma, Inc., a clinical-stage biopharmaceutical company, is engineering a novel class of injectable biologics to selectively engage and modulate targeted T cells within the body to transform the treatment of cancer, infectious disease and autoimmune disease. Cue Biopharma is a high growth company and is listed on NASDAQ (CUE). The company is located in Cambridge, Massachusetts in the heart of the life sciences corridor.

Cue Biopharma is building a world-class team of highly motivated, dedicated scientists to help us advance our research and development programs. The company culture is fast-paced and committed to scientific excellence, innovation and teamwork.

Candidate Profile

The successful candidate will have a strong scientific background with hands-on experience developing and troubleshooting purification processes for protein-based biologic products. The candidate must also have experience in scaling up/down, tech transfer and in-depth understanding of cGMP in order to develop scalable, robust and effective processes.

Key Responsibilities

  • Serve as the protein purification process development subject matter expert on the Protein Discovery team. Develop processes and generate documents including batch records, summary and technical reports.
  • Design and execute experiments, collect and analyze data. Present process analyses, trends and summaries to the group in a timely manner.
  • Generate, enhance and enrich process understanding knowledge. Initiate novel process/technology when applicable.
  • Assist with cell culture and in-process analysis work when needed.
  • Make strong technical contributions to cross functional development project teams to ensure efficient and timely execution of deliverables.
  • Collaborate with other teams and CDMO partners in designing manufacturing processes and assist with tech transfer activities.
  • Contribute to relevant sections of IND filings and other documentation.

Requirements

  • BS in an applicable field of study with at least 10 years of industry experience, or MS in an applicable field of study with at least 8 years of industry experience, or Ph.D. in an applicable field of study with at least 5 years of industry experience.
  • Significant experience developing and troubleshooting protein purification processes.
  • The successful candidate will be proficient in all unit operations and related software of DSP including chromatography, normal and tangential filtration instruments.
  • Experience with AKTA Avant or Pure.
  • DSP related process analytics experience in process performance, protein quality and residuals.
  • Experience with Fc fusion proteins is strongly preferred as well as experience with monoclonal antibodies.
  • Protein formulation experience is a plus. Knowledge of DS and DP process desired.
  • DOE experience is strongly preferred.
  • Experience with statistical software such as JMP or Minitab.
  • Understanding of QbD is a plus.
  • Cell culture experience or knowledge is a plus.
  • cGMP collaboration experience preferred including experience with technical reviewing.
  • Strong desire and curiosity to develop a novel class of therapeutic proteins.

To apply, please email your resume to careers@cuebio.com. In the subject line include your name and the posted job title.

« Go Back