Careers

Scientist/Senior Scientist, Protein Analytics

Cue Biopharma, Inc., a clinical-stage biopharmaceutical company, is engineering a novel class of injectable biologics to selectively engage and modulate targeted T cells within the body to transform the treatment of cancer and autoimmune diseases. Cue Biopharma is a high growth company and is listed on NASDAQ (CUE). The company is located in Cambridge, Massachusetts in the heart of the life sciences corridor.

Cue Biopharma is building a world-class team of highly motivated, dedicated scientists to help us advance our research and development programs. The company culture is fast-paced and committed to scientific excellence, innovation, and teamwork.

Candidate Profile

We are seeking a motivated Scientist/Senior Scientist to lead our biophysical characterization and protein analytics efforts in developing new and novel molecules for therapeutic applications. The successful candidate will provide guidance and data-driven support for the nomination of drug product candidates for preclinical development. The Scientist/Senior Scientist will have hands-on experience in assay development and analytical characterization, and excellent technical skills with the ability to play a critical role in identifying developability of molecules and working with multi-disciplinary teams to drive project advancements.

Key Responsibilities

  • Maintain and expand state-of-the-art Protein Analytics platforms to support analytical screening and characterization of Cue Biopharma fusion molecules having diverse and novel modalities.
  • Design and perform targeted biophysical and biochemical experiments to guide selection of lead candidates based on maximizing preclinical developability success.
  • Develop assays to identify and characterize potential liabilities of early discovery molecules and engage in solutions toward mitigation strategies.
  • Identify and coordinate with external CRO on biophysical characterization needs, beyond internally available techniques, to expand the understanding of Cue Biopharma molecules.
  • Active collaboration with project teams across the organization to accelerate programs toward development.
  • Work with fellow scientists to enhance biophysical and drug development knowledge and provide technical guidance in experimental design, implementation and analysis.
  • Stay up to date with scientific literature and advancements in the field of protein biophysics and characterization. Apply as appropriate to streamline workflow and improve efficiency.
  • Generate, manage, evaluate and maintain critical data in a highly organized manner. Author and review internal SOPs and analytical reports. Contribute to the development of external publications, posters and presentations.
  • Effectively communicate results through written documentation and oral presentations across multidisciplinary teams.
  • Manage multiple parallel project timelines and deliverables and coordinate directly with project leads.
  • Maintain extensive lab presence and perform hands-on work.

Requirements

  • Ph.D. degree in a scientific discipline with 3+ years relevant experience, MS with 5+ years relevant experience, or BS with 8+ years of relevant experience.
  • Strong understanding and hands-on expertise in a wide range of biophysical and analytical methods including chromatography-based methods, (e.g., SEC, HIC, IEX), light scattering (DLS and MALS), thermal stability (DSC and DSF), stress studies and formulation screen.
  • Prior industry experience in hands-on analytical characterization of biologics is required.
  • Demonstrated experience with biochemical (ELISA, AlphaLISA, TR-FRET, etc) and biophysical (BLI/SPR/ITC) assay development to characterize protein-protein interactions.
  • Prior protein purification and qualification and mass spec experience is highly desirable.
  • Must demonstrate a keen knowledge of experimental design, underlying scientific principles and the ability to critically analyze and assess results. 
  • Must maintain a high level of scientific rigor and attention to details.
  • Must maintain good laboratory practice including safety guideline compliance and timely notebook updates.
  • Demonstrate ability to work in a team environment, keeping pace with a high ¬≠functioning group of scientists and adaptive to perform multiple needs in support of project advancements.

To apply, please email your resume to careers@cuebio.com In the subject line include your name and the posted job title.

« Go Back